Genetic Variant rs1800795 (G>C) in the Interleukin 6 (IL6) Gene and Susceptibility to Coronary-Artery Diseases, Type 2 Diabetes, Acute Pancreatitis, Rheumatoid Arthritis, and Bronchial Asthma in Asians: A Comprehensive Meta-Analysis Based on 30154 Subjects

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DOI:

https://doi.org/10.47852/bonviewMEDIN42021996

Keywords:

rs1800795, meta-analysis, Asian, CAD, rheumatoid arthritis

Abstract

Numerous studies conducted globally have explored the possible connection between the IL6 gene variant rs1800795 (G>C) and the risk of several diseases. Nonetheless, the correlation specifically within the Asian population remains inconclusive. Hence, this extensive meta-analysis aims to establish a conclusive correlation between the rs1800795 variant and susceptibility to various diseases among Asians. 50 eligible articles were chosen from Google Scholar, PubMed, Web of Science, and PMC based on specific inclusion criteria. Odds ratios alongside 95% CI (confidence intervals) were utilized. Additionally, subgroup analysis, publication bias, and sensitivity evaluation were conducted. The analysis, of 14,737 cases and 15,417 controls, showed a notable correlation between the rs1800795 (G>C) SNP and the overall disease susceptibility to all models (p-value <2.5E-05). The ethnicity-specific stratified findings indicated that: the C-allele of (C vs. G) model of -174G/C polymorphism expressively elevated the overall disease susceptibility in both East and South Asian populations. The disease-based stratified analyses suggested that the C variant of rs1800795 was related to coronary artery diseases and bronchial asthma (under all models), type 2 diabetes (CG vs. GG), acute pancreatitis (C vs. G; and CC vs. GG), rheumatoid arthritis (CC+CG vs. GG; CC vs. CG+GG; and C vs. G), and acute pancreatitis (C or CC vs. G or GG respectively). IL6 rs1800795 polymorphism is a highly significant disease risk factor in Asians and can potentially serve as a prognostic biomarker for future disease screening and evaluation.

 

Received: 3 November 2023 | Revised: 18 December 2023 | Accepted: 31 December 2023

 

Conflicts of Interest

The author declares that he has no conflicts of interest to this work.

 

Data Availability Statement

The article and supplementary material present the study's original findings, for additional inquiries, please contact the corresponding author.

 

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Published

2024-01-12

How to Cite

Harun-Or-Roshid, M., Mollah, M. N. H., & Jesmin. (2024). Genetic Variant rs1800795 (G>C) in the Interleukin 6 (IL6) Gene and Susceptibility to Coronary-Artery Diseases, Type 2 Diabetes, Acute Pancreatitis, Rheumatoid Arthritis, and Bronchial Asthma in Asians: A Comprehensive Meta-Analysis Based on 30154 Subjects. Medinformatics. https://doi.org/10.47852/bonviewMEDIN42021996

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Research Articles